Beyond Omega-3: EPAX® Evolve 05

EPAX® Evolve 05 is a marine Omega-3 concentrated formula containing lipids that go beyond long-chain EPA and DHA. Epax has developed technology to produce a concentrated oil abundant in very long chain polyunsaturated fatty acids (VLC-PUFA).

Published

The protein ELOVL2 normally produces VLC-PUFAs but during aging this activity is reduced. The association between chronological aging and ELOVL2 gene activity is extremely tight and can be used as a biological clock [1]. This gives the tantalising offer that EPAX Evolve 05 may restore age related decline in VLC-PUFAs.

VLC-PUFAs are essential for vision, for male fertility, for skin health and for brain development. Studies show that reduced ELOVL2 activity results in accelerated aging (muscle strength, bone density, hair loss) and genetic pre-clinical and human studies confirm the essential nature of VLC-PUFA in these areas [2].

The importance of VLC-PUFAs in retinal function received a boost when ELOVL4 mutations were shown to be the cause of Stargardt 3, a condition resulting in juvenile visual impairment. In 2023, a breakthrough study was performed using a fish-derived VLC-PUFA oil. Oral intake of this oil led to improved retinal function[3]. This study not only demonstrated rescue of vision by supplementa¬tion but provided an important example that supplemental VLC-PUFA can indeed affect the structure and function of the body resulting in a health benefit.

Possible health targets for EPAX® Evolve 05 supplementation:

• Eye health

• Male reproductive health

• Skin health

• Brain health

• Bone health

EPAX® Evolve 05 is the first commercially available VLC-PUFA concentrate from fish oil. Join us in exploring this paradigm shift in Omega-3 nutrition.

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1. Paparazzo, E., et al., An ELOVL2-Based Epigenetic Clock for Forensic Age Prediction: A Systematic Review. Int J Mol Sci, 2023. 24(3).

2. Li, X., et al., Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging. Signal Transduct Target Ther, 2022. 7(1): p. 162.

3. Yang, Z.H., et al., Dietary fish oil enriched in very-long-chain polyunsaturated fatty acid reduces cardiometabolic risk factors and improves retinal function. iScience, 2023.

26(12): p. 108411.

This article presents scientific findings and areas of scientific research with Very Long Chain Polyunsaturated Fatty Acids. These findings have not been evaluated by regulatory authorities and do not represent authorised nutritional claims.